Growth factor-regulated pathways in epithelial cell proliferation

S. A. Aaronson, J. S. Rubin, P. W. Finch, J. Wong, C. Marchese, J. Falco, W. G. Taylor, M. H. Kraus

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Investigations of the pathways regulating normal growth of epithelial cells have revealed the existence of two major growth-factor signaling cascades required for proliferation. One pathway is activated by IGF-1 or high insulin concentration. The other is triggered by EGF, TGFα, or members of the FGF family, including the recently discovered epithelial-cell-specific growth factor, designated keratinocyte growth factor (KGF). Its expression pattern in vivo suggests that KGF plays an important normal physiologic role as a stromal effector of epithelial cell proliferation. Oncogenes, which represent constitutively activated forms of genes critically involved in growth-factor signaling pathways, specifically abrogate the requirement for mitogens of the EGF pathway. Examples of such genes include the erbB/EGF receptor and erbB-2, which encode structurally related receptor proteins and are often amplified and/or overexpressed in epithelial malignancies. Employing reduced stringency hybridization with v-erbB as a probe, we recently identified a third member of this receptor family, designated erbB-3. cDNA cloning revealed a predicted 148-kD transmembrane polypeptide with structural features similar to those of the EGF receptor. Normal erbB-3 expression in keratinocytes and glandular epithelium suggests its physiologic role in these cell types. Moreover, markedly elevated erbB-3 mRNA levels in certain mammary tumor cell lines suggest that increased erbB-3 expression may also play a role in some human epithelial malignancies.

Original languageEnglish
Pages (from-to)S7-S10
JournalAmerican Review of Respiratory Disease
Issue number6 SUPPL.
StatePublished - 1990
Externally publishedYes


Dive into the research topics of 'Growth factor-regulated pathways in epithelial cell proliferation'. Together they form a unique fingerprint.

Cite this