@article{f3b4abb56169493da56292c00585d760,
title = "Greater Neonatal Fat-Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain",
abstract = "Objective: The objective of this study was to determine the effectiveness of controlling maternal gestational weight gain (GWG) in the second and third trimesters on neonate body composition. Methods: Two hundred ten healthy women with overweight (25 > BMI < 30) or obesity (BMI ≥ 30) were randomly assigned to a lifestyle intervention (LI) program focused on controlling GWG through nutrition and activity behaviors or to usual obstetrical care (UC). Infant fat and fat-free mass (FFM) at birth were measured by using air displacement plethysmography (PEA POD) and by using quantitative magnetic resonance (QMR). Results: At baseline, there were no between-group differences in maternal characteristics (mean [SD]): age: 33.8 (4.3) years, weight: 81.9 (13.7) kg, BMI: 30.4 (4.5), and gestational age at randomization: 14.9 (0.8) weeks. GWG was less in the LI group by 1.79 kg (P = 0.003) or 0.0501 kg/wk (P = 0.002). Compared with UC infants, LI infants had greater weight (131 ± 59 g P = 0.03), FFM (98 ± 45 g; P = 0.03) measured by PEA POD, and lean mass (105 ± 38 g; P = 0.006) measured by QMR. Fat mass and percent fat were not significantly different. Conclusions: Intervening in women with overweight and obesity through behaviors promoting healthy diet and physical activity to control GWG resulted in neonates with similar fat and greater FFM.",
author = "Dympna Gallagher and Barak Rosenn and Tatiana Toro-Ramos and Charles Paley and Sonia Gidwani and Michelle Horowitz and Janet Crane and Susan Lin and Thornton, {John C.} and Xavier Pi-Sunyer",
note = "Funding Information: See Commentary, pg. 459. Funding agencies: This work was supported by NIH grants U01-DK094463, U01-DK094463-Supplement (supplement to promote diversity, TTR), P30-DK026687, and T32-DK007559. The content is the responsibility of the authors and does not necessarily represent the official views of the NIH. The Lifestyle Interventions for Expectant Moms consortium is supported by the NIH through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (U01 DK094418, U01 DK094463, U01DK094416, and 5U01DK094466 [RCU]), the National Heart, Lung, and Blood Institute (U01HL114344 and U01HL114377), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (U01 HD072834), the National Center for Complementary and Integrative Health, the NIH Office of Research in Women{\textquoteright}s Health, the Office of Behavioral and Social Science Research, the Indian Health Service, and the Intramural Research Program of the NIDDK. Disclosure: The authors declared no conflict of interest. Author contributions: DG, XP, JCT, and BR designed the study; DG and XP are coprincipal investigators of the Lifestyle Intervention for Two trial and were responsible for supervision of data collection; BR was responsible for obstetrical care; TTR, CP, and SG were responsible for newborn outcome measures; MH was the primary project coordinator; JC was the primary lifestyle interventionist; SL was responsible for data management; JCT was responsible for data analysis; and DG and XP had primary responsibility for final content. All authors read and approved the final manuscript. Clinical trial registration: ClinicalTrials.gov identifier NCT01616147. Additional Supporting Information may be found in the online version of this article. Received: 9 August 2017; Accepted: 30 October 2017; Published online 21 February 2018. doi:10.1002/oby.22079 Funding Information: We thank the LIFE-Moms consortium members for their contributions to the development and oversight of common measures and procedures across the trials; the LIFT study participants (women and infants) for enrolling in this study; the LIFT staff for their herculean efforts: Kasey Faulkner, Maryanne Holowaty, Isaiah Janumala, Jill Johnson, Kim Kelly, Rachel Koletsky, Jennifer Patricio, Julie Roman, Elizabeth Widen, and Wen Yu; and Rebecca Gersnoviez Clifton, PhD, at The George Washington University Biostatistics Center for guidance specific to LIFE-Moms consortium outcomes and definitions. Publisher Copyright: {\textcopyright} 2018 The Obesity Society",
year = "2018",
month = mar,
doi = "10.1002/oby.22079",
language = "English",
volume = "26",
pages = "578--587",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "3",
}