Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes

Roni Lotan; Ramit Ravona-Springer; Jacob Mandel; Hung Mo Lin; Yuxia Ouyang; Danit R. Shahar; Sharon Bezalel; Puja Agarwal; Klodian Dhana; Anthony Heymann; Mary Sano; Michal Schnaider Beeri

doi:10.1016/j.diabres.2022.109989

Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes

Roni Lotan, Ramit Ravona-Springer, Jacob Mandel, Hung Mo Lin, Yuxia Ouyang, Danit R. Shahar, Sharon Bezalel, Puja Agarwal, Klodian Dhana, Anthony Heymann, Mary Sano, Michal Schnaider Beeri

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.

Original language	English
Article number	109989
Journal	Diabetes Research and Clinical Practice
Volume	190
DOIs	https://doi.org/10.1016/j.diabres.2022.109989
State	Published - Aug 2022

Keywords

Cognitive decline
Dietary patterns
Older adults
Type 2 diabetes

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10.1016/j.diabres.2022.109989

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Lotan, R., Ravona-Springer, R., Mandel, J., Lin, H. M., Ouyang, Y., Shahar, D. R., Bezalel, S., Agarwal, P., Dhana, K., Heymann, A., Sano, M., & Schnaider Beeri, M. (2022). Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes. Diabetes Research and Clinical Practice, 190, Article 109989. https://doi.org/10.1016/j.diabres.2022.109989

@article{445885715ab444fe9243b6f205280179,

title = "Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes",

abstract = "Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.",

keywords = "Cognitive decline, Dietary patterns, Older adults, Type 2 diabetes",

author = "Roni Lotan and Ramit Ravona-Springer and Jacob Mandel and Lin, {Hung Mo} and Yuxia Ouyang and Shahar, {Danit R.} and Sharon Bezalel and Puja Agarwal and Klodian Dhana and Anthony Heymann and Mary Sano and {Schnaider Beeri}, Michal",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = aug,

doi = "10.1016/j.diabres.2022.109989",

language = "English",

volume = "190",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

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Lotan, R, Ravona-Springer, R, Mandel, J, Lin, HM, Ouyang, Y, Shahar, DR, Bezalel, S, Agarwal, P, Dhana, K, Heymann, A, Sano, M & Schnaider Beeri, M 2022, 'Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes', Diabetes Research and Clinical Practice, vol. 190, 109989. https://doi.org/10.1016/j.diabres.2022.109989

TY - JOUR

T1 - Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes

AU - Lotan, Roni

AU - Ravona-Springer, Ramit

AU - Mandel, Jacob

AU - Lin, Hung Mo

AU - Ouyang, Yuxia

AU - Shahar, Danit R.

AU - Bezalel, Sharon

AU - Agarwal, Puja

AU - Dhana, Klodian

AU - Heymann, Anthony

AU - Sano, Mary

AU - Schnaider Beeri, Michal

PY - 2022/8

Y1 - 2022/8

N2 - Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.

AB - Aims: To determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D). Methods: This is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline. Results: The mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively). Conclusions: In older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.

KW - Cognitive decline

KW - Dietary patterns

KW - Older adults

KW - Type 2 diabetes

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U2 - 10.1016/j.diabres.2022.109989

DO - 10.1016/j.diabres.2022.109989

M3 - Article

C2 - 35820563

AN - SCOPUS:85134617891

SN - 0168-8227

VL - 190

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

M1 - 109989

ER -

Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes

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Keywords

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