Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

Jun Wang, Lap Ho, Wei Zhao, Kenjiro Ono, Clark Rosensweig, Linghong Chen, Nelson Humala, David B. Teplow, Giulio M. Pasinetti

Research output: Contribution to journalArticlepeer-review

342 Scopus citations

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) Aβ oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576 mice, a model of AD. In this study, we found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into high-molecular-weight oligomers in vitro. When orally administered to Tg2576 mice, this polyphenolic preparation significantly attenuates AD-type cognitive deterioration coincidentally with reduced HMW soluble oligomeric Aβ in the brain. Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.

Original languageEnglish
Pages (from-to)6388-6392
Number of pages5
JournalJournal of Neuroscience
Volume28
Issue number25
DOIs
StatePublished - 18 Jun 2008

Keywords

  • Alzheimer's disease
  • Amyloid β
  • Aβ peptide
  • Cognitive
  • Dementia
  • Morris water maze
  • Spatial memory

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