Granulocyte colony-stimulating factor: Preclinical and clinical studies

J. L. Gabrilove, A. Jakubowski

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The production of neutrophil granulocytes is a complex and dynamic process during which a small number of self-renewing stem cells give rise to lineage-specific progenitors. One hematopoietic glycoprotein that appears to specifically cotnrol the survival, cycle activation, proliferation and terminal maturation of this myeloid lineage is granulocyte colony-stimulating factor (G-CSF). Some topics discussed are its molecular characterization, biochemical purification, sources, and effects of administration.

Original languageEnglish
Pages (from-to)427-440
Number of pages14
JournalHematology/Oncology Clinics of North America
Issue number3
StatePublished - 1989
Externally publishedYes


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