GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation

Tomas Castro-Dopico; Aaron Fleming; Thomas W. Dennison; John R. Ferdinand; Katherine Harcourt; Benjamin J. Stewart; Zaeem Cader; Zewen K. Tuong; Chenzhi Jing; Laurence S.C. Lok; Rebeccah J. Mathews; Anaïs Portet; Arthur Kaser; Simon Clare; Menna R. Clatworthy

doi:10.1016/j.celrep.2020.107857

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation

Tomas Castro-Dopico
, Aaron Fleming
, Thomas W. Dennison
, John R. Ferdinand
, Katherine Harcourt
, Benjamin J. Stewart
, Zaeem Cader
, Zewen K. Tuong
, Chenzhi Jing
, Laurence S.C. Lok
, Rebeccah J. Mathews
, Anaïs Portet
, Arthur Kaser
, Simon Clare
, Menna R. Clatworthy

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Castro-Dopico et al. identify GM-CSF as a major upstream regulator of intestinal inflammatory macrophages, with ILC-derived GM-CSF polarizing macrophages toward a glycolytic, anti-microbial phenotype while suppressing wound-healing, pro-fibrotic activity. GM-CSF initiates further ILC-macrophage crosstalk, amplifying ILC3 activation and type 17 immunity.

Original language	English
Article number	107857
Journal	Cell Reports
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.107857
State	Published - 7 Jul 2020
Externally published	Yes

Keywords

GM-CSF
anti-microbial defense
crosstalk
inflammatory bowel disease
innate lymphoid cells
macrophages
wound healing

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10.1016/j.celrep.2020.107857

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Castro-Dopico, T., Fleming, A., Dennison, T. W., Ferdinand, J. R., Harcourt, K., Stewart, B. J., Cader, Z., Tuong, Z. K., Jing, C., Lok, L. S. C., Mathews, R. J., Portet, A., Kaser, A., Clare, S., & Clatworthy, M. R. (2020). GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation. Cell Reports, 32(1), Article 107857. https://doi.org/10.1016/j.celrep.2020.107857

@article{3118c20f46e2491aa0499cd024010013,

title = "GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation",

abstract = "Castro-Dopico et al. identify GM-CSF as a major upstream regulator of intestinal inflammatory macrophages, with ILC-derived GM-CSF polarizing macrophages toward a glycolytic, anti-microbial phenotype while suppressing wound-healing, pro-fibrotic activity. GM-CSF initiates further ILC-macrophage crosstalk, amplifying ILC3 activation and type 17 immunity.",

keywords = "GM-CSF, anti-microbial defense, crosstalk, inflammatory bowel disease, innate lymphoid cells, macrophages, wound healing",

author = "Tomas Castro-Dopico and Aaron Fleming and Dennison, \{Thomas W.\} and Ferdinand, \{John R.\} and Katherine Harcourt and Stewart, \{Benjamin J.\} and Zaeem Cader and Tuong, \{Zewen K.\} and Chenzhi Jing and Lok, \{Laurence S.C.\} and Mathews, \{Rebeccah J.\} and Ana{\"i}s Portet and Arthur Kaser and Simon Clare and Clatworthy, \{Menna R.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = jul,

day = "7",

doi = "10.1016/j.celrep.2020.107857",

language = "English",

volume = "32",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "1",

}

Castro-Dopico, T, Fleming, A, Dennison, TW, Ferdinand, JR, Harcourt, K, Stewart, BJ, Cader, Z, Tuong, ZK, Jing, C, Lok, LSC, Mathews, RJ, Portet, A, Kaser, A, Clare, S & Clatworthy, MR 2020, 'GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation', Cell Reports, vol. 32, no. 1, 107857. https://doi.org/10.1016/j.celrep.2020.107857

TY - JOUR

T1 - GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation

AU - Castro-Dopico, Tomas

AU - Fleming, Aaron

AU - Dennison, Thomas W.

AU - Ferdinand, John R.

AU - Harcourt, Katherine

AU - Stewart, Benjamin J.

AU - Cader, Zaeem

AU - Tuong, Zewen K.

AU - Jing, Chenzhi

AU - Lok, Laurence S.C.

AU - Mathews, Rebeccah J.

AU - Portet, Anaïs

AU - Kaser, Arthur

AU - Clare, Simon

AU - Clatworthy, Menna R.

PY - 2020/7/7

Y1 - 2020/7/7

N2 - Castro-Dopico et al. identify GM-CSF as a major upstream regulator of intestinal inflammatory macrophages, with ILC-derived GM-CSF polarizing macrophages toward a glycolytic, anti-microbial phenotype while suppressing wound-healing, pro-fibrotic activity. GM-CSF initiates further ILC-macrophage crosstalk, amplifying ILC3 activation and type 17 immunity.

AB - Castro-Dopico et al. identify GM-CSF as a major upstream regulator of intestinal inflammatory macrophages, with ILC-derived GM-CSF polarizing macrophages toward a glycolytic, anti-microbial phenotype while suppressing wound-healing, pro-fibrotic activity. GM-CSF initiates further ILC-macrophage crosstalk, amplifying ILC3 activation and type 17 immunity.

KW - GM-CSF

KW - anti-microbial defense

KW - crosstalk

KW - inflammatory bowel disease

KW - innate lymphoid cells

KW - macrophages

KW - wound healing

UR - https://www.scopus.com/pages/publications/85087423469

U2 - 10.1016/j.celrep.2020.107857

DO - 10.1016/j.celrep.2020.107857

M3 - Article

C2 - 32640223

AN - SCOPUS:85087423469

SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 1

M1 - 107857

ER -

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation

Abstract

Keywords

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