TY - JOUR
T1 - Glyphosate exposures and kidney injury biomarkers in infants and young children
AU - Trasande, Leonardo
AU - Aldana, Sandra India
AU - Trachtman, Howard
AU - Kannan, Kurunthachalam
AU - Morrison, Deborah
AU - Christakis, Dimitri A.
AU - Whitlock, Kathryn
AU - Messito, Mary Jo
AU - Gross, Rachel S.
AU - Karthikraj, Rajendiran
AU - Sathyanarayana, Sheela
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects, few have examined potential effects on kidney function in children. We leveraged three cohorts across different phases of child development and measured urinary levels of glyphosate. We evaluated associations of glyphosate with three biomarkers of kidney injury: albuminuria (ACR), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury marker 1 (KIM-1). Multivariable regression analyses examined associations of glyphosate with kidney injury biomarkers controlling for covariates. We identified glyphosate in 11.1% of the total participants. The herbicide was detected more frequently in the neonate population (30%). Multivariable regression models failed to identify significant associations of log-transformed glyphosate with any of the kidney injury biomarkers, controlling for covariates age, sex, and maternal education. While we confirm detectability of glyphosate in children's urine at various ages and stages of life, there is no evidence in this study for renal injury in children exposed to low levels of glyphosate. Further studies of larger sample size are indicated to better understand putative deleterious effects of the herbicide after different levels of exposure. Glyphosate is detectable is the urine of 11% of infants and young children (30% of neonates). However, there is no association with albuminuria or biomarkers of renal tubular injury.
AB - The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects, few have examined potential effects on kidney function in children. We leveraged three cohorts across different phases of child development and measured urinary levels of glyphosate. We evaluated associations of glyphosate with three biomarkers of kidney injury: albuminuria (ACR), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury marker 1 (KIM-1). Multivariable regression analyses examined associations of glyphosate with kidney injury biomarkers controlling for covariates. We identified glyphosate in 11.1% of the total participants. The herbicide was detected more frequently in the neonate population (30%). Multivariable regression models failed to identify significant associations of log-transformed glyphosate with any of the kidney injury biomarkers, controlling for covariates age, sex, and maternal education. While we confirm detectability of glyphosate in children's urine at various ages and stages of life, there is no evidence in this study for renal injury in children exposed to low levels of glyphosate. Further studies of larger sample size are indicated to better understand putative deleterious effects of the herbicide after different levels of exposure. Glyphosate is detectable is the urine of 11% of infants and young children (30% of neonates). However, there is no association with albuminuria or biomarkers of renal tubular injury.
KW - Children
KW - Environmental exposures
KW - Glyphosate
KW - Nephrotoxicity
KW - Renal biomarkers
UR - http://www.scopus.com/inward/record.url?scp=85074488430&partnerID=8YFLogxK
U2 - 10.1016/j.envpol.2019.113334
DO - 10.1016/j.envpol.2019.113334
M3 - Article
C2 - 31677874
AN - SCOPUS:85074488430
SN - 0269-7491
VL - 256
JO - Environmental Pollution
JF - Environmental Pollution
M1 - 113334
ER -