TY - JOUR
T1 - Glycotoxins in the diet promote diabetes and diabetic complications
AU - Vlassara, Helen
AU - Striker, Gary
PY - 2007/6
Y1 - 2007/6
N2 - Oxidant stress underlines diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation and products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.
AB - Oxidant stress underlines diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation and products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.
UR - http://www.scopus.com/inward/record.url?scp=34250726548&partnerID=8YFLogxK
U2 - 10.1007/s11892-007-0037-z
DO - 10.1007/s11892-007-0037-z
M3 - Review article
C2 - 17547841
AN - SCOPUS:34250726548
SN - 1534-4827
VL - 7
SP - 235
EP - 241
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 3
ER -