Glycoconjugate synthesis using chemoselective ligation

Shuihong Cheng; Paeton L. Wantuch; Megan E. Kizer; Dustin R. Middleton; Ruitong Wang; Mikaela Dibello; Mingli Li; Xing Wang; Xuebing Li; Vasanthi Ramachandiran; Fikri Y. Avci; Fuming Zhang; Xing Zhang; Robert J. Linhardt

doi:10.1039/c9ob00270g

Glycoconjugate synthesis using chemoselective ligation

Shuihong Cheng
, Paeton L. Wantuch
, Megan E. Kizer
, Dustin R. Middleton
, Ruitong Wang
, Mikaela Dibello
, Mingli Li
, Xing Wang
, Xuebing Li
, Vasanthi Ramachandiran
, Fikri Y. Avci
, Fuming Zhang
, Xing Zhang
, Robert J. Linhardt

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Original language	English
Pages (from-to)	2646-2650
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	17
Issue number	10
DOIs	https://doi.org/10.1039/c9ob00270g
State	Published - 2019
Externally published	Yes

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title = "Glycoconjugate synthesis using chemoselective ligation",

abstract = "Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.",

author = "Shuihong Cheng and Wantuch, \{Paeton L.\} and Kizer, \{Megan E.\} and Middleton, \{Dustin R.\} and Ruitong Wang and Mikaela Dibello and Mingli Li and Xing Wang and Xuebing Li and Vasanthi Ramachandiran and Avci, \{Fikri Y.\} and Fuming Zhang and Xing Zhang and Linhardt, \{Robert J.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c9ob00270g",

language = "English",

volume = "17",

pages = "2646--2650",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - Glycoconjugate synthesis using chemoselective ligation

AU - Cheng, Shuihong

AU - Wantuch, Paeton L.

AU - Kizer, Megan E.

AU - Middleton, Dustin R.

AU - Wang, Ruitong

AU - Dibello, Mikaela

AU - Li, Mingli

AU - Wang, Xing

AU - Li, Xuebing

AU - Ramachandiran, Vasanthi

AU - Avci, Fikri Y.

AU - Zhang, Fuming

AU - Zhang, Xing

AU - Linhardt, Robert J.

PY - 2019

Y1 - 2019

N2 - Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

AB - Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

UR - https://www.scopus.com/pages/publications/85062620917

U2 - 10.1039/c9ob00270g

DO - 10.1039/c9ob00270g

M3 - Article

C2 - 30778481

AN - SCOPUS:85062620917

SN - 1477-0520

VL - 17

SP - 2646

EP - 2650

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 10

ER -

Glycoconjugate synthesis using chemoselective ligation

Abstract

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