TY - JOUR
T1 - Glutathione S-transferase polymorphisms and oral cancer
T2 - A case-control study in Rio de Janeiro, Brazil
AU - Hatagima, Ana
AU - Costa, Emmerson C.B.
AU - Marques, Christiane F.S.
AU - Koifman, Rosalina J.
AU - Boffetta, Paolo
AU - Koifman, Sergio
N1 - Funding Information:
The authors are grateful to the dedicated and skilled work of the interviewers and medical staff from the Head and Neck Service, Brazilian National Cancer Institute (INCA), whose cooperation was essential to carry out this investigation. The authors also thank Dr. Paul Brennan for helpful comments and critical reading of the manuscript and Dr. Pedro H. Cabello for his statistical comments. This work was supported by Grants from Oswaldo Cruz Foundation (FIOCRUZ), Brazilian National Research Council (CNPq), and European Community (DG XII – Grant IC18 CT970222).
PY - 2008/2
Y1 - 2008/2
N2 - This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro. DNA extracted from white blood cells of 231 oral cancer patients and 212 hospital controls was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. GSTM1 polymorphism distribution was different between cases and controls (P = 0.006), with an overrepresentation of GSTM1 A/B genotype in controls. GSTM1 A/B individuals were at decreased oral cancer risk (OR = 0.08; 95% CI = 0.05-0.62). No statistically significant association was observed for GSTT1 and GSTP1 polymorphisms. Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer. Therefore, these results do not support the hypothesis of increased risk of GSTP1 G/G, GSTM1 or GSTT1 null genotypes for developing cancer in oral cavity, but the GSTM1 A/B genotype emerged as a protective factor.
AB - This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro. DNA extracted from white blood cells of 231 oral cancer patients and 212 hospital controls was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. GSTM1 polymorphism distribution was different between cases and controls (P = 0.006), with an overrepresentation of GSTM1 A/B genotype in controls. GSTM1 A/B individuals were at decreased oral cancer risk (OR = 0.08; 95% CI = 0.05-0.62). No statistically significant association was observed for GSTT1 and GSTP1 polymorphisms. Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer. Therefore, these results do not support the hypothesis of increased risk of GSTP1 G/G, GSTM1 or GSTT1 null genotypes for developing cancer in oral cavity, but the GSTM1 A/B genotype emerged as a protective factor.
KW - Brazil
KW - GSTM1
KW - GSTP1
KW - GSTT1
KW - Genetic polymorphism
KW - Molecular epidemiology
KW - Oral cancer
UR - https://www.scopus.com/pages/publications/38849143893
U2 - 10.1016/j.oraloncology.2007.02.001
DO - 10.1016/j.oraloncology.2007.02.001
M3 - Article
C2 - 17418613
AN - SCOPUS:38849143893
SN - 1368-8375
VL - 44
SP - 200
EP - 207
JO - Oral Oncology
JF - Oral Oncology
IS - 2
ER -