Abstract
Glutamine synthetase and glutamyl transferase activity have been assayed in the neocortex, hippocampus, cerebellum, diencephalon, and ponsmedulla of developing kittens and mature animals. The method used for synthetase assay enabled the determination of enzyme activity in homogenates of whole brain tissue. The five brain areas showed different patterns of development for the enzyme. The neocortex had the sharpest increase in enzyme activity and achieved the highest values. In the neocortex the rate of enzyme development coincided with the pattern of development of the compartmentation of glutamic acid metabolism (Berl, 1965); this was not true for the other brain areas (Berl and Purpura, 1965).
| Original language | English |
|---|---|
| Pages (from-to) | 916-922 |
| Number of pages | 7 |
| Journal | Biochemistry |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Mar 1966 |
| Externally published | Yes |
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