Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

Chadi G. Abdallah; Lynnette A. Averill; John H. Krystal; Steven M. Southwick; Amy F.T. Arnsten

doi:10.1017/S0140525X15001727

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

Chadi G. Abdallah
, Lynnette A. Averill
, John H. Krystal
, Steven M. Southwick
, Amy F.T. Arnsten

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.

Original language	English
Pages (from-to)	e201
Journal	The Behavioral and brain sciences
Volume	39
DOIs	https://doi.org/10.1017/S0140525X15001727
State	Published - 1 Jan 2016
Externally published	Yes

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title = "Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology",

abstract = "Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.",

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AU - Abdallah, Chadi G.

AU - Averill, Lynnette A.

AU - Krystal, John H.

AU - Southwick, Steven M.

AU - Arnsten, Amy F.T.

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AB - Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.

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VL - 39

SP - e201

JO - The Behavioral and brain sciences

JF - The Behavioral and brain sciences

ER -

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

Abstract

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