Glucose metabolic changes in nontumoral brain tissue of patients with brain tumor following radiotherapy: A preliminary study

Gene Jack Wang, Nora D. Volkow, Yat Hong Lau, Joanna S. Fowler, Allen G. Meek, Tae L. Park, Christopher Wong, Clemente T. Roque, Arvin J. Adler, Alfred P. Wolf

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Purpose: Our goal was to measure the effect of radiotherapy on the brain glucose metabolism of tumoral and nontumoral tissue of patients with brain malignancies. Method: Fifteen patients with primary or metastatic brain tumors were studied with 2-deoxy-2-[18F]fluoro-D-glucose and PET prior to radiotherapy, and nine of them were rescanned 1 week after completing radiotherapy. Results: Brain metabolism in patients (all brain regions except for tumoral and edematous tissue) was lower than that of matched controls (34.0 ± 8.3 vs. 46.5 ± 6.4 μmol/100 g/min; p ≤ 0.0001). Five of the nine patients retested after radiotherapy showed decrements in tumor metabolism (47 ± 10%; p ≤ 0.05) and increases in brain metabolism (10 ± 4%; p ≤ 0.004), and the other four showed no changes in tumor or in brain metabolism. Radiotherapy-induced changes in tumor metabolism were negatively correlated with changes in brain metabolism (r = 0.85, p ≤ 0.004), but not with changes in tumor volume (assessed with MR images). Conclusion: The study indicates that radiotherapy-induced increases in metabolism of nontumoral tissue are secondary to decreased tumor metabolic activity and not just due to volume reduction.

Original languageEnglish
Pages (from-to)709-714
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume20
Issue number5
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Brain, metabolism
  • Brain, neoplasms
  • Emission computed tomography
  • Radiation, effects

Fingerprint

Dive into the research topics of 'Glucose metabolic changes in nontumoral brain tissue of patients with brain tumor following radiotherapy: A preliminary study'. Together they form a unique fingerprint.

Cite this