Glucocorticosteroids associated with a decreased risk of psychosis

Wijnand Laan, Hugo Smeets, Niek J. De Wit, René S. Kahn, Diederick E. Grobbee, Huibert Burger

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.

Original languageEnglish
Pages (from-to)288-290
Number of pages3
JournalJournal of Clinical Psychopharmacology
Issue number3
StatePublished - Jun 2009
Externally publishedYes


  • Glucocorticosteroids
  • Inflammation
  • Psychosis
  • Schizophrenia


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