TY - JOUR
T1 - Glucagon-like peptide-1
T2 - a multi-faceted anti-inflammatory agent
AU - Mehdi, Syed Faizan
AU - Pusapati, Suma
AU - Anwar, Muhammad Saad
AU - Lohana, Durga
AU - Kumar, Parkash
AU - Nandula, Savitri Aninditha
AU - Nawaz, Fatima Kausar
AU - Tracey, Kevin
AU - Yang, Huan
AU - LeRoith, Derek
AU - Brownstein, Michael J.
AU - Roth, Jesse
N1 - Publisher Copyright:
Copyright © 2023 Mehdi, Pusapati, Anwar, Lohana, Kumar, Nandula, Nawaz, Tracey, Yang, LeRoith, Brownstein and Roth.
PY - 2023
Y1 - 2023
N2 - Inflammation contributes to many chronic conditions. It is often associated with circulating pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity. They are often elevated and can serve as markers of inflammation. Previous studies have shown that oxytocin, hCG, ghrelin, alpha-MSH and ACTH have receptor-mediated anti-inflammatory properties that can rescue cells from damage and death. These peptides have been studied well in the past century. In contrast, GLP-1 and its anti-inflammatory properties have been recognized only recently. GLP-1 has been proven to be a useful adjuvant therapy in type-2 diabetes mellitus, metabolic syndrome, and hyperglycemia. It also lowers HbA1C and protects cells of the cardiovascular and nervous systems by reducing inflammation and apoptosis. In this review we have explored the link between GLP-1, inflammation, and sepsis.
AB - Inflammation contributes to many chronic conditions. It is often associated with circulating pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity. They are often elevated and can serve as markers of inflammation. Previous studies have shown that oxytocin, hCG, ghrelin, alpha-MSH and ACTH have receptor-mediated anti-inflammatory properties that can rescue cells from damage and death. These peptides have been studied well in the past century. In contrast, GLP-1 and its anti-inflammatory properties have been recognized only recently. GLP-1 has been proven to be a useful adjuvant therapy in type-2 diabetes mellitus, metabolic syndrome, and hyperglycemia. It also lowers HbA1C and protects cells of the cardiovascular and nervous systems by reducing inflammation and apoptosis. In this review we have explored the link between GLP-1, inflammation, and sepsis.
KW - GLP-1 - glucagon-like peptide-1
KW - GLP-1 agonists
KW - anti-inflammation
KW - hormone
KW - incretin
KW - inflammation
UR - http://www.scopus.com/inward/record.url?scp=85160969156&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2023.1148209
DO - 10.3389/fimmu.2023.1148209
M3 - Review article
C2 - 37266425
AN - SCOPUS:85160969156
SN - 1664-3224
VL - 14
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1148209
ER -