Glomerular lesions in mice transgenic for growth hormone and insulinlike growth factor-I: I. Relationship between increased glomerular size and mesangial sclerosis

Toshio Doi, Liliane J. Striker, Carter C. Gibson, Lawrence Y.C. Agodoa, Ralph L. Brinster, Gary E. Striker

Research output: Contribution to journalArticlepeer-review

189 Scopus citations

Abstract

The glomeruli of mice transgenic for bovine growth hormone (GH mice) were disproportionately enlarged as a function of either kidney or body weight. Glomerular size correlated with mesangial sclerosis and the urine albumin/creatinine ratio. The glomerular lesions consisted of mesangial proliferation (4 to 5 weeks) followed by progressive mesangial sclerosis (19 weeks), resulting in complete glomerulosclerosis at 30 to 37 weeks. Albuminuria paralleled the glomerulosclerosis. In contrast, mice transgenic for insulinlike growth factor-I (IGF-I mice) did not develop glomerulosclerosis, even though glomerular size significantly increased. Glomerular hypertrophy, however, did not reach that in GH mice. These data suggest that high levels of circulating GH lead to a disproportionate increase in glomerular cellularity and volume, as well as glomerulosclerosis. This does not appear to be the result of high levels of circulating IGF-I stimulated by GH, as the serum IGF-I level in GH mice was lower than that in IG-FI mice.

Original languageEnglish
Pages (from-to)541-552
Number of pages12
JournalAmerican Journal of Pathology
Volume137
Issue number3
StatePublished - Sep 1990
Externally publishedYes

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