TY - JOUR
T1 - Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy
AU - Akalin, Enver
AU - Dikman, S.
AU - Murphy, B.
AU - Bromberg, J. S.
AU - Hancock, W. W.
PY - 2003/9
Y1 - 2003/9
N2 - The pathogeneses of chronic allograft nephropathy (CAN), a leading cause of allograft failure, and one of its complications, transplant glomerulopathy (TGP), are unknown. Immunohistologic analysis of human renal transplant biopsies showed expression of inducible costimulator (ICOS), the chemokine receptor CXCR3, and its ligands, Mig and IP-10, by intraglomerular and periglomerular leukocytes in biopsies with CAN and TGP but not CAN alone. ICOS and CXCR3 are both characteristics of activated, effector T cells, suggesting different pathogenetic mechanisms underlying TGP vs. CAN. We conclude that targeting of specific chemokine and chemokine receptor pathways and/or ICOS may have clinical application in the prevention and treatment of TGP.
AB - The pathogeneses of chronic allograft nephropathy (CAN), a leading cause of allograft failure, and one of its complications, transplant glomerulopathy (TGP), are unknown. Immunohistologic analysis of human renal transplant biopsies showed expression of inducible costimulator (ICOS), the chemokine receptor CXCR3, and its ligands, Mig and IP-10, by intraglomerular and periglomerular leukocytes in biopsies with CAN and TGP but not CAN alone. ICOS and CXCR3 are both characteristics of activated, effector T cells, suggesting different pathogenetic mechanisms underlying TGP vs. CAN. We conclude that targeting of specific chemokine and chemokine receptor pathways and/or ICOS may have clinical application in the prevention and treatment of TGP.
KW - CXCR3
KW - Chemokines
KW - Chronic allograft nephropathy
KW - ICOS
KW - Transplant glomerulopathy
UR - http://www.scopus.com/inward/record.url?scp=0041861305&partnerID=8YFLogxK
U2 - 10.1034/j.1600-6143.2003.00151.x
DO - 10.1034/j.1600-6143.2003.00151.x
M3 - Article
C2 - 12919091
AN - SCOPUS:0041861305
SN - 1600-6135
VL - 3
SP - 1116
EP - 1120
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 9
ER -