Global informatics and physical property selection in protein sequences

Harold A. Scheraga, S. Rackovsky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The degree of informatic independence between the physical properties of amino acids as encoded in actual protein sequences is calculated. It is shown that no physical property can be identified that carries significantly less information than others and that the information overlap between different properties and different length scales along the sequence is essentially zero. These observations suggest that bioinformatic models based on arbitrarily selected .sets of physical properties are inherently deficient.

Original languageEnglish
Pages (from-to)1808-1810
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number7
StatePublished - 16 Feb 2016


  • Fourier analysis
  • Information theory
  • Physical properties
  • Protein bioinformatics


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