Glaucoma and Ocular Surface Disease: More than Meets the Eye

Gavin Li, Esen Karamursel Akpek, Sumayya Ahmad

Research output: Contribution to journalReview articlepeer-review


Understanding the association between ocular surface disease and glaucoma is important for improving adherence to treatment and introducing practical solutions. While topical antihypertensive medications for glaucoma are well tolerated according to short-term studies, there is little evidence on their long-term effects. Since they are often required for many years, the effects of these drops on the ocular surface become important in regard to quality of life and adherence. In this nonsystematic review performed in April 2022, we summarize what is known about the relationship between glaucoma and ocular surface disease. Specifically, we examine how each class of topical glaucoma drops affects the ocular surface. We then review the treatment of ocular surface disease for patients on topical glaucoma therapy. Finally, we discuss treatments that may reduce or eliminate the burden of topical medications.

Original languageEnglish
Pages (from-to)3641-3649
Number of pages9
JournalClinical Ophthalmology
StatePublished - 2022


  • adherence
  • glaucoma
  • ocular surface disease


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