Giant lymph node hyperplasia (Castleman's disease): A clinical study of eight patients

Yaacov Baruch, Yehudith Ben-Arie, Hedviga Kerner, Margalit Lorber, Lael Anson Best, Ruth Gershoni-Baruch

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


We report on 8 patients with giant lymph node hyperplasia (GLNH), diagnosed over a 10-year period. The age of the patients at diagnosis, the clinical presentation and the histological subtype varied, indicating that GNLH is a heterogeneous condition. One case was associated with liver cirrhosis, and in another patient bacterial endocarditis was diagnosed post mortem. Our study shows that GLNH is localized and benign in the young, and diffuse and aggressive in the elderly. It is concluded that GLNH should be separated into 3 clinical entities - namely, localized, systemic and reactive GLNH - defined by their clinical presentation and course, and correlated or not correlated with the histological findings.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalPostgraduate Medical Journal
Issue number786
StatePublished - 1991
Externally publishedYes


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