Giant cell tumor complicating Paget disease of long bone

Benjamin Hoch, George Hermann, Michael J. Klein, Ibrahim Fikry Abdelwahab, Dempsey Springfield

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22 Scopus citations


Giant cell tumor (GCT) is a rare complication of Paget disease of bone. It usually occurs in the skull or pelvic bones of patients with long-standing polyostotic disease. This report describes a 62-year-old patient who presented with monostotic Paget disease of the distal femur complicated by GCT. He had a 2-year history of discomfort and pain in his left knee. Conventional plain films and MRI demonstrated the characteristic bone changes of Paget disease and an associated lytic lesion involving the epiphyseal and metaphyseal regions of the distal femur. A diagnostic curettage showed the characteristic histopathologic features of Paget disease and GCT. There was no evidence of malignancy. The clinicopathologic features of this rare lesion are described and correlated with a review of the literature.

Original languageEnglish
Pages (from-to)973-978
Number of pages6
JournalSkeletal Radiology
Issue number10
StatePublished - Oct 2007
Externally publishedYes


  • Bone tumor
  • Giant cell tumor
  • Paget disease


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