GH administration decreases subcutaneous abdominal adipocyte size in men with abdominal obesity

Miriam A. Bredella, Kalypso Karastergiou, Stijn A. Bos, Anu V. Gerweck, Martin Torriani, Susan K. Fried, Karen K. Miller

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective To investigate the effects of short-term GH administration on abdominal subcutaneous adipocyte size and CT attenuation in men with abdominal obesity. Design 6-week, randomized, double-blind, placebo-controlled study of GH (starting dose 2 μg/kg/d) vs placebo of 15 abdominally obese men (mean age: 34 ± 6 years; mean BMI: 37.7 ± 6.1 kg/m2, mean IGF-1 SDS: − 1.9 ± 0.5) who underwent abdominal subcutaneous adipose tissue (SAT) aspirations to determine adipocyte size, CTs for body composition and measures of glucose tolerance at baseline and 6 weeks. GH dosing was titrated to target IGF-1 levels in the upper normal age-appropriate range. Results GH administration decreased subcutaneous abdominal adipocyte size compared to placebo. Adipocyte size was positively associated with 120-min glucose and HOMA-IR and inversely associated with peak-stimulated GH and CT attenuation. CT attenuation of SAT was inversely associated with 120-min glucose and HOMA-IR and increased following GH administration. Conclusion In men with abdominal obesity, subcutaneous abdominal adipocyte size is positively associated with measures of impaired glucose tolerance and administration of GH at doses that raise IGF-1 levels within the normal range, decreases abdominal subcutaneous adipocyte size, suggesting that GH administration improves the health of adipose tissue.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalGrowth Hormone and IGF Research
Volume35
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • Adipocytes
  • Adipose tissue
  • Adiposity
  • Computed tomography
  • Growth hormone
  • Obesity

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