Gestational age of previous twin preterm birth as a predictor for subsequent singleton preterm birth

Timothy J. Rafael, Matthew K. Hoffman, Benjamin E. Leiby, Vincenzo Berghella

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: We sought to determine an optimal gestational-age cutoff of preterm twin deliveries for predicting subsequent singleton preterm birth (PTB). Study Design: We performed a retrospective study of women with a spontaneous twin delivery who subsequently had a singleton gestation. Univariate and multivariate analyses determined the risk of a spontaneous singleton PTB after a PTB of a twin gestation. Different gestational-age cutoffs of the previous twin PTB were evaluated. Results: Among 255 women, previous twin PTB at <34 weeks' gestation was associated with an increased risk of singleton PTB (odds ratio, 9.67; 95% confidence interval, 3.0730.47). Every twin gestational age cutoff at <34 weeks' gestation had a significantly higher risk of subsequent singleton PTB, which was no longer significant at <34 weeks' gestation (odds ratio, 1.68; 95% confidence interval, 0.2312.19). Conclusion: In women with a previous spontaneous twin PTB at <34 weeks' gestation, there is an increased risk of subsequent singleton PTB. A twin birth at <34 weeks' gestation is not associated with an increased risk for a subsequent singleton PTB.

Original languageEnglish
Pages (from-to)156.e1-156.e6
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
StatePublished - Feb 2012
Externally publishedYes


  • gestational age
  • preterm birth
  • singleton
  • twins


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