TY - JOUR
T1 - Germinal center reaction
T2 - Antigen affinity and presentation explain it all
AU - Oropallo, Michael A.
AU - Cerutti, Andrea
PY - 2014/7
Y1 - 2014/7
N2 - The selection and expansion of B cells undergoing affinity maturation in the germinal center is a hallmark of humoral immunity. A recent paper in Nature provides new insights into the relationships between the affinity of the immunoglobulin receptor for antigen, the ability of B cells to present antigen to T cells, and the processes of selection, mutation, and clonal expansion in the germinal center.
AB - The selection and expansion of B cells undergoing affinity maturation in the germinal center is a hallmark of humoral immunity. A recent paper in Nature provides new insights into the relationships between the affinity of the immunoglobulin receptor for antigen, the ability of B cells to present antigen to T cells, and the processes of selection, mutation, and clonal expansion in the germinal center.
KW - Affinity maturation
KW - Antigen presentation
KW - Germinal center
KW - Tfh cells
UR - http://www.scopus.com/inward/record.url?scp=84903517553&partnerID=8YFLogxK
U2 - 10.1016/j.it.2014.06.001
DO - 10.1016/j.it.2014.06.001
M3 - Short survey
C2 - 24934509
AN - SCOPUS:84903517553
SN - 1471-4906
VL - 35
SP - 287
EP - 289
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -