Genotype-First Approach Identifies an Association between rs28374544/FOG2^S657G and Liver Disease through Alterations in mTORC1 Signaling

Keyphrases

• Liver Disease 100%
• GATA2 100%
• MTORC1 Signaling 100%
• Genotype-first Approach 100%
• Metabolic-associated Fatty Liver Disease (MAFLD) 100%
• Hepatocytes 66%
• De-novo Lipogenesis 66%
• Fatty Acids 66%
• Lipid Accumulation 66%
• Liver Failure 33%
• Molecular Mechanism 33%
• Meta-analysis 33%
• Cirrhosis 33%
• Liver Injury 33%
• Transcriptional Repressor 33%
• Mammalian Target of Rapamycin (mTOR) 33%
• Induced Pluripotent Stem Cells (iPSCs) 33%
• Cardiometabolic Disease 33%
• African Ancestry 33%
• Stem Cell Lines 33%
• Hepatic Lipid Accumulation 33%
• Biobank 33%
• Minor Allele Frequency 33%
• Differential Gene Expression Analysis 33%
• Huh7 33%
• Coding Variants 33%
• Liposome Transfection 33%
• Expression Gene 33%
• Gene Set Enrichment Analysis 33%
• Oxidative Phosphorylation (OXPHOS) 33%
• Hepatic Lipid Metabolism 33%
• Triglyceride Synthesis 33%
• Genomic Datasets 33%
• Molecular Landscape 33%
• Human Hepatoma Cells 33%
• MTORC1 Pathway 33%

Biochemistry, Genetics and Molecular Biology

• Lipid Storage 100%
• Genotyping 100%
• GATA2 100%
• Hepatocyte 66%
• Lipogenesis 66%
• Lipid 33%
• Lipid Liver Level 33%
• Wild Type 33%
• Stem Cell Line 33%
• Downregulation 33%
• Lipid Metabolism 33%
• Gene Expression Profiling 33%
• Triglyceride 33%
• Minor Allele Frequency 33%
• Differential Gene Expression 33%
• Oxidative Phosphorylation 33%
• Transfection 33%
• Genomics 33%
• Genome-Wide Analysis of Gene Expression 33%
• Human Induced Pluripotent Stem Cell 33%