@article{e2e708f550984514ad7b40838b48b9af,
title = "Genomics in CKD: Is This the Path Forward?",
abstract = "Recent advances in genomics and sequencing technology have led to a better understanding of genetic risk in CKD. Genetics could account in part for racial differences in treatment response for medications including antihypertensives and immunosuppressive medications due to its correlation with ancestry. However, there is still a substantial lag between generation of this knowledge and its adoption in routine clinical care. This review summarizes the recent advances in genomics and CKD, discusses potential reasons for its underutilization, and highlights potential avenues for application of genomic information to improve clinical care and outcomes in this particularly vulnerable population.",
keywords = "CKD, Disparities, Genetics, Genomics, Pharmacogenomics",
author = "Nadkarni, {Girish N.} and Horowitz, {Carol R.}",
note = "Funding Information: This work is supported by NHGRI (5U01HG007278, U01HG006380) and NCATS (UL1TR000067). Neither NHGRI nor NCATS had any involvement in the interpretation of data or writing the article. The authors would also like to thank the GUARDD team of academic, community, clinical partners, study coordinators, and staff at study sites, and their partners in the IGNITE Network, a consortium of genomic medicine pilot demonstration projects funded and guided by the NHGRI, for their valuable contributions to this project. We would also like to thank Erwin B{\"o}ttinger for his leadership and vision. Funding Information: This work is supported by NHGRI ( 5U01HG007278, U01HG006380 ) and NCATS ( UL1TR000067 ). Neither NHGRI nor NCATS had any involvement in the interpretation of data or writing the article. The authors would also like to thank the GUARDD team of academic, community, clinical partners, study coordinators, and staff at study sites, and their partners in the IGNITE Network, a consortium of genomic medicine pilot demonstration projects funded and guided by the NHGRI, for their valuable contributions to this project. We would also like to thank Erwin B{\"o}ttinger for his leadership and vision. Publisher Copyright: {\textcopyright} 2016 National Kidney Foundation, Inc.",
year = "2016",
month = mar,
day = "1",
doi = "10.1053/j.ackd.2016.01.017",
language = "English",
volume = "23",
pages = "120--124",
journal = "Advances in Chronic Kidney Disease",
issn = "1548-5595",
publisher = "W.B. Saunders Ltd",
number = "2",
}