Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

Jeffrey R. Kugelman; Sara C. Johnston; Prime M. Mulembakani; Neville Kisalu; Michael S. Lee; Galina Koroleva; Sarah E. McCarthy; Marie C. Gestole; Nathan D. Wolfe; Joseph N. Fair; Bradley S. Schneider; Linda L. Wright; John Huggins; Chris A. Whitehouse; Emile Okitolonda Wemakoy; Jean Jacques Muyembe-Tamfum; Lisa E. Hensley; Gustavo F. Palacios; Anne W. Rimoin

doi:10.3201/eid2002.130118

Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

Jeffrey R. Kugelman, Sara C. Johnston, Prime M. Mulembakani, Neville Kisalu, Michael S. Lee, Galina Koroleva, Sarah E. McCarthy, Marie C. Gestole, Nathan D. Wolfe, Joseph N. Fair, Bradley S. Schneider, Linda L. Wright, John Huggins, Chris A. Whitehouse, Emile Okitolonda Wemakoy, Jean Jacques Muyembe-Tamfum, Lisa E. Hensley, Gustavo F. Palacios, Anne W. Rimoin

Research output: Contribution to journal › Article › peer-review

249 Scopus citations

Abstract

Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance.

Original language	English
Pages (from-to)	232-239
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	20
Issue number	2
DOIs	https://doi.org/10.3201/eid2002.130118
State	Published - Feb 2014
Externally published	Yes

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Kugelman, J. R., Johnston, S. C., Mulembakani, P. M., Kisalu, N., Lee, M. S., Koroleva, G., McCarthy, S. E., Gestole, M. C., Wolfe, N. D., Fair, J. N., Schneider, B. S., Wright, L. L., Huggins, J., Whitehouse, C. A., Wemakoy, E. O., Muyembe-Tamfum, J. J., Hensley, L. E., Palacios, G. F., & Rimoin, A. W. (2014). Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. Emerging Infectious Diseases, 20(2), 232-239. https://doi.org/10.3201/eid2002.130118

@article{675a47cdd65f4febad489778f9ba82ef,

title = "Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo",

abstract = "Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance.",

author = "Kugelman, {Jeffrey R.} and Johnston, {Sara C.} and Mulembakani, {Prime M.} and Neville Kisalu and Lee, {Michael S.} and Galina Koroleva and McCarthy, {Sarah E.} and Gestole, {Marie C.} and Wolfe, {Nathan D.} and Fair, {Joseph N.} and Schneider, {Bradley S.} and Wright, {Linda L.} and John Huggins and Whitehouse, {Chris A.} and Wemakoy, {Emile Okitolonda} and Muyembe-Tamfum, {Jean Jacques} and Hensley, {Lisa E.} and Palacios, {Gustavo F.} and Rimoin, {Anne W.}",

year = "2014",

month = feb,

doi = "10.3201/eid2002.130118",

language = "English",

volume = "20",

pages = "232--239",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

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}

Kugelman, JR, Johnston, SC, Mulembakani, PM, Kisalu, N, Lee, MS, Koroleva, G, McCarthy, SE, Gestole, MC, Wolfe, ND, Fair, JN, Schneider, BS, Wright, LL, Huggins, J, Whitehouse, CA, Wemakoy, EO, Muyembe-Tamfum, JJ, Hensley, LE, Palacios, GF & Rimoin, AW 2014, 'Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo', Emerging Infectious Diseases, vol. 20, no. 2, pp. 232-239. https://doi.org/10.3201/eid2002.130118

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T1 - Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

AU - Kugelman, Jeffrey R.

AU - Johnston, Sara C.

AU - Mulembakani, Prime M.

AU - Kisalu, Neville

AU - Lee, Michael S.

AU - Koroleva, Galina

AU - McCarthy, Sarah E.

AU - Gestole, Marie C.

AU - Wolfe, Nathan D.

AU - Fair, Joseph N.

AU - Schneider, Bradley S.

AU - Wright, Linda L.

AU - Huggins, John

AU - Whitehouse, Chris A.

AU - Wemakoy, Emile Okitolonda

AU - Muyembe-Tamfum, Jean Jacques

AU - Hensley, Lisa E.

AU - Palacios, Gustavo F.

AU - Rimoin, Anne W.

PY - 2014/2

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AB - Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance.

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Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

Abstract

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