Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases

McKinzie K.A. Garrison, Yeongjun Jang, Taejeong Bae, Adriana Cherskov, Sarah B. Emery, Liana Fasching, Attila Jones, John B. Moldovan, Cindy Molitor, Sirisha Pochareddy, Mette A. Peters, Joo Heon Shin, Yifan Wang, Xiaoxu Yang, Schahram Akbarian, Andrew Chess, Fred H. Gage, Joseph G. Gleeson, Jeffrey M. Kidd, Michael McConnellRyan E. Mills, John V. Moran, Peter J. Park, Nenad Sestan, Alexander E. Urban, Flora M. Vaccarino, Christopher A. Walsh, Daniel R. Weinberger, Sarah J. Wheelan, Alexej Abyzov, Aitor Serres Amero, Danny Antaki, Dan Averbuj, Laurel Ball, Sara Bizzotto, Craig Bohrson, Rebeca Borges-Monroy, Martin Breuss, Sean Cho, Chong Chu, Changuk Chung, Isidro Cortes-Ciriano, Michael Coulter, Kenneth Daily, Caroline Dias, Alissa D’Gama, Yanmei Dou, Jennifer Erwin, Diane A. Flasch, Trenton J. Frisbie, Alon Galor, Javier Ganz, Doga Gulhan, Robert Hill, August Yue Huang, Andrew Jaffe, Alexandre Jourdon, David Juan, Sattar Khoshkhoo, Sonia Kim, Huira C. Kopera, Kenneth Y. Kwan, Minseok Kwon, Ben Langmead, Eunjung Alice Lee, Sara Linker, Irene Lobon, Michael A. Lodato, Lovelace J. Luquette, Gary Mathern, Tomas Marques-Bonet, Eduardo A. Maury, Michael Miller, Manuel Solis Moruno, Rujuta Narurkar, Apua Paquola, Reenal Pattni, Raquel Garcia Perez, Inna Povolotskaya, Patrick Reed, Rachel Rodin, Chaggai Rosenbluh, Soraya Scuderi, Maxwell Sherman, Richard Straub, Eduardo Soriano, Chen Sun, Jeremy Thorpe, Vinay Viswanadham, Meiyan Wang, Xuefang Zhao, Bo Zhou, Weichen Zhou, Zinan Zhou, Xiaowei Zhu

Research output: Contribution to journalArticlepeer-review

Abstract

Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in autism spectrum disorder, bipolar disorder, focal cortical dysplasia, schizophrenia, and Tourette syndrome, a multi-institutional consortium called the Brain Somatic Mosaicism Network (BSMN) was formed through the National Institute of Mental Health (NIMH). In addition to genomic data of affected and neurotypical brains, the BSMN also developed and validated a best practices somatic single nucleotide variant calling workflow through the analysis of reference brain tissue. These resources, which include >400 terabytes of data from 1087 subjects, are now available to the research community via the NIMH Data Archive (NDA) and are described here.

Original languageEnglish
Article number813
JournalScientific data
Volume10
Issue number1
DOIs
StatePublished - Dec 2023

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