TY - JOUR
T1 - Genomic correction of familial cardiomyopathy in human engineered cardiac tissues
AU - Stillitano, Francesca
AU - Turnbull, Irene C.
AU - Karakikes, Ioannis
AU - Nonnenmacher, Mathieu
AU - Backeris, Peter
AU - Hulot, Jean Sébastien
AU - Kranias, Evangelia G.
AU - Hajjar, Roger J.
AU - Costa, Kevin D.
N1 - Publisher Copyright:
© The Author 2016.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.
AB - In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.
KW - Dilated cardiomyopathy
KW - Engineered heart tissue
KW - Gene editing
KW - Induced pluripotent stem cells
KW - Phospholamban
UR - http://www.scopus.com/inward/record.url?scp=85013641801&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehw307
DO - 10.1093/eurheartj/ehw307
M3 - Article
C2 - 27450564
AN - SCOPUS:85013641801
SN - 0195-668X
VL - 37
SP - 3282
EP - 3284
JO - European Heart Journal
JF - European Heart Journal
IS - 43
ER -