Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Francesca Stillitano, Irene C. Turnbull, Ioannis Karakikes, Mathieu Nonnenmacher, Peter Backeris, Jean Sébastien Hulot, Evangelia G. Kranias, Roger J. Hajjar, Kevin D. Costa

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

Original languageEnglish
Pages (from-to)3282-3284
Number of pages3
JournalEuropean Heart Journal
Volume37
Issue number43
DOIs
StatePublished - 1 Nov 2016

Keywords

  • Dilated cardiomyopathy
  • Engineered heart tissue
  • Gene editing
  • Induced pluripotent stem cells
  • Phospholamban

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