TY - JOUR
T1 - Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
AU - Pillas, Demetris
AU - Hoggart, Clive J.
AU - Evans, David M.
AU - O'Reilly, Paul F.
AU - Sipilä, Kirsi
AU - Lähdesmäki, Raija
AU - Millwood, Iona Y.
AU - Kaakinen, Marika
AU - Netuveli, Gopalakrishnan
AU - Blane, David
AU - Charoen, Pimphen
AU - Sovio, Ulla
AU - Pouta, Anneli
AU - Freimer, Nelson
AU - Hartikainen, Anna Liisa
AU - Laitinen, Jaana
AU - Vaara, Sarianna
AU - Glaser, Beate
AU - Crawford, Peter
AU - Timpson, Nicholas J.
AU - Ring, Susan M.
AU - Deng, Guohong
AU - Zhang, Weihua
AU - McCarthy, Mark I.
AU - Deloukas, Panos
AU - Peltonen, Leena
AU - Elliott, Paul
AU - Coin, Lachlan J.M.
AU - Smith, George Davey
AU - Jarvelin, Marjo Riitta
PY - 2010/2
Y1 - 2010/2
N2 - Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10 -8, and 5 with suggestive association (P<5×10-6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.
AB - Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10 -8, and 5 with suggestive association (P<5×10-6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.
UR - https://www.scopus.com/pages/publications/77649210349
U2 - 10.1371/journal.pgen.1000856
DO - 10.1371/journal.pgen.1000856
M3 - Article
C2 - 20195514
AN - SCOPUS:77649210349
SN - 1553-7390
VL - 6
JO - PLoS Genetics
JF - PLoS Genetics
IS - 2
M1 - e1000856
ER -