@article{d5f28b9e446a43a89d3d9cece27455dd,
title = "Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa",
abstract = "Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9–4% of women and 0.3% of men2–4, with twin-based heritability estimates of 50–60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.",
author = "{Anorexia Nervosa Genetics Initiative} and {Eating Disorders Working Group of the Psychiatric Genomics Consortium} and Watson, {Hunna J.} and Zeynep Yilmaz and Thornton, {Laura M.} and Christopher H{\"u}bel and Coleman, {Jonathan R.I.} and Gaspar, {H{\'e}l{\'e}na A.} and Julien Bryois and Anke Hinney and Lepp{\"a}, {Virpi M.} and Manuel Mattheisen and Medland, {Sarah E.} and Stephan Ripke and Shuyang Yao and Paola Giusti-Rodr{\'i}guez and Hanscombe, {Ken B.} and Purves, {Kirstin L.} and Adan, {Roger A.H.} and Lars Alfredsson and Tetsuya Ando and Andreassen, {Ole A.} and Baker, {Jessica H.} and Berrettini, {Wade H.} and Ilka Boehm and Claudette Boni and Perica, {Vesna Boraska} and Katharina Buehren and Roland Burghardt and Matteo Cassina and Sven Cichon and Maurizio Clementi and Cone, {Roger D.} and Philippe Courtet and Scott Crow and Crowley, {James J.} and Danner, {Unna N.} and Davis, {Oliver S.P.} and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and DeSocio, {Janiece E.} and Dick, {Danielle M.} and Dimitris Dikeos and Christian Dina and Monika Dmitrzak-Weglarz and Elisa Docampo and Duncan, {Laramie E.} and Karin Egberts and Huckins, {Laura M.} and Nadia Micali and Dalila Pinto",
note = "Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2019",
month = aug,
day = "1",
doi = "10.1038/s41588-019-0439-2",
language = "English",
volume = "51",
pages = "1207--1214",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "8",
}