Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Fan Wang, Cheng Qi Xu, Qing He, Jian Ping Cai, Xiu Chun Li, Dan Wang, Xin Xiong, Yu Hua Liao, Qiu Tang Zeng, Yan Zong Yang, Xiang Cheng, Cong Li, Rong Yang, Chu Chu Wang, Gang Wu, Qiu Lun Lu, Ying Bai, Yu Feng Huang, Dan Yin, Qing YangXiao Jing Wang, Da Peng Dai, Rong Feng Zhang, Jing Wan, Jiang Hua Ren, Si Si Li, Yuan Yuan Zhao, Fen Fen Fu, Yuan Huang, Qing Xian Li, Sheng Wei Shi, Nan Lin, Zhen Wei Pan, Yue Li, Bo Yu, Yan Xia Wu, Yu He Ke, Jian Lei, Nan Wang, Chun Yan Luo, Li Ying Ji, Lian Jun Gao, Lei Li, Hui Liu, Er Wen Huang, Jin Cui, Na Jia, Xiang Ren, Hui Li, Tie Ke, Xian Qin Zhang, Jing Yu Liu, Mu Gen Liu, Hao Xia, Bo Yang, Li Song Shi, Yun Long Xia, Xin Tu, Qing K. Wang

Research output: Contribution to journalArticlepeer-review

224 Scopus citations

Abstract

Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00-10'3, stage 2 validation; P = 3.00 - 103, P = 1.19 - 10 '8 and P = 4.00 - 10 '3 in three independent stage 3 replication populations; P = 4.87 - 10'12, odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.

Original languageEnglish
Pages (from-to)345-351
Number of pages7
JournalNature Genetics
Volume43
Issue number4
DOIs
StatePublished - Feb 2011
Externally publishedYes

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