Genome-wide asociation analysis identifies three psoriasis susceptibility loci

Philip E. Stuart; Rajan P. Nair; Eva ELinghaus; Jun Ding; Trilokraj Tejasvi; Johan E. GudjonSon; Yun Li; Stephan Weidinger; Bernadete Eberlein; Christian Gieger; H. Erich WichmaN; Manfred Kunz; Robert Ike; Gerald G. Krueger; Ane M. Bowcock; Ulrich Mrowietz; Henry W. Lim; John J. VOrhEs; Gonçalo R. Abecasis; Michael Weichenthal; Andre Franke; Proton Rahman; Dafna D. Gladman; James T. Elder

doi:10.1038/ng.693

Genome-wide asociation analysis identifies three psoriasis susceptibility loci

Philip E. Stuart
, Rajan P. Nair
, Eva ELinghaus
, Jun Ding
, Trilokraj Tejasvi
, Johan E. GudjonSon
, Yun Li
, Stephan Weidinger
, Bernadete Eberlein
, Christian Gieger
, H. Erich WichmaN
, Manfred Kunz
, Robert Ike
, Gerald G. Krueger
, Ane M. Bowcock
, Ulrich Mrowietz
, Henry W. Lim
, John J. VOrhEs
, Gonçalo R. Abecasis
, Michael Weichenthal

Andre Franke, Proton Rahman, Dafna D. Gladman, James T. Elder

Research output: Contribution to journal › Article › peer-review

293 Scopus citations

Abstract

We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10^-11), one at FBXL19 (rs10782001, combined P = 9-10^-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10^-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10^-5; rs10782001, combined P = 4-10^-8; and rs12586317, combined P = 6-10^-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10^-8; rs10782001, combined P = 2-10^-6; and rs12586317, combined P = 1-10^-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10^-7).

Original language	English
Pages (from-to)	1000-1004
Number of pages	5
Journal	Nature Genetics
Volume	42
Issue number	11
DOIs	https://doi.org/10.1038/ng.693
State	Published - Nov 2010
Externally published	Yes

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Stuart, P. E., Nair, R. P., ELinghaus, E., Ding, J., Tejasvi, T., GudjonSon, J. E., Li, Y., Weidinger, S., Eberlein, B., Gieger, C., WichmaN, H. E., Kunz, M., Ike, R., Krueger, G. G., Bowcock, A. M., Mrowietz, U., Lim, H. W., VOrhEs, J. J., Abecasis, G. R., ... Elder, J. T. (2010). Genome-wide asociation analysis identifies three psoriasis susceptibility loci. Nature Genetics, 42(11), 1000-1004. https://doi.org/10.1038/ng.693

@article{aa15b8743368475886294fcafec74860,

title = "Genome-wide asociation analysis identifies three psoriasis susceptibility loci",

abstract = "We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).",

author = "Stuart, \{Philip E.\} and Nair, \{Rajan P.\} and Eva ELinghaus and Jun Ding and Trilokraj Tejasvi and GudjonSon, \{Johan E.\} and Yun Li and Stephan Weidinger and Bernadete Eberlein and Christian Gieger and WichmaN, \{H. Erich\} and Manfred Kunz and Robert Ike and Krueger, \{Gerald G.\} and Bowcock, \{Ane M.\} and Ulrich Mrowietz and Lim, \{Henry W.\} and VOrhEs, \{John J.\} and Abecasis, \{Gon{\c c}alo R.\} and Michael Weichenthal and Andre Franke and Proton Rahman and Gladman, \{Dafna D.\} and Elder, \{James T.\}",

year = "2010",

month = nov,

doi = "10.1038/ng.693",

language = "English",

volume = "42",

pages = "1000--1004",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "11",

}

Stuart, PE, Nair, RP, ELinghaus, E, Ding, J, Tejasvi, T, GudjonSon, JE, Li, Y, Weidinger, S, Eberlein, B, Gieger, C, WichmaN, HE, Kunz, M, Ike, R, Krueger, GG, Bowcock, AM, Mrowietz, U, Lim, HW, VOrhEs, JJ, Abecasis, GR, Weichenthal, M, Franke, A, Rahman, P, Gladman, DD & Elder, JT 2010, 'Genome-wide asociation analysis identifies three psoriasis susceptibility loci', Nature Genetics, vol. 42, no. 11, pp. 1000-1004. https://doi.org/10.1038/ng.693

TY - JOUR

T1 - Genome-wide asociation analysis identifies three psoriasis susceptibility loci

AU - Stuart, Philip E.

AU - Nair, Rajan P.

AU - ELinghaus, Eva

AU - Ding, Jun

AU - Tejasvi, Trilokraj

AU - GudjonSon, Johan E.

AU - Li, Yun

AU - Weidinger, Stephan

AU - Eberlein, Bernadete

AU - Gieger, Christian

AU - WichmaN, H. Erich

AU - Kunz, Manfred

AU - Ike, Robert

AU - Krueger, Gerald G.

AU - Bowcock, Ane M.

AU - Mrowietz, Ulrich

AU - Lim, Henry W.

AU - VOrhEs, John J.

AU - Abecasis, Gonçalo R.

AU - Weichenthal, Michael

AU - Franke, Andre

AU - Rahman, Proton

AU - Gladman, Dafna D.

AU - Elder, James T.

PY - 2010/11

Y1 - 2010/11

N2 - We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).

AB - We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).

UR - https://www.scopus.com/pages/publications/78049323656

U2 - 10.1038/ng.693

DO - 10.1038/ng.693

M3 - Article

C2 - 20953189

AN - SCOPUS:78049323656

SN - 1061-4036

VL - 42

SP - 1000

EP - 1004

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Genome-wide asociation analysis identifies three psoriasis susceptibility loci

Abstract

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