TY - JOUR
T1 - Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
AU - BMES GWAS Group
AU - NEIGHBORHOOD Consortium
AU - Hysi, Pirro G.
AU - Cheng, Ching Yu
AU - Springelkamp, Henriët
AU - Macgregor, Stuart
AU - Cooke Bailey, Jessica N.
AU - Wojciechowski, Robert
AU - Vitart, Veronique
AU - Nag, Abhishek
AU - Hewitt, Alex W.
AU - Höhn, René
AU - Venturini, Cristina
AU - Mirshahi, Alireza
AU - Ramdas, Wishal D.
AU - Thorleifsson, Gudmar
AU - Vithana, Eranga
AU - Khor, Chiea Chuen
AU - Stefansson, Arni B.
AU - Liao, Jiemin
AU - Haines, Jonathan L.
AU - Amin, Najaf
AU - Wang, Ya Xing
AU - Wild, Philipp S.
AU - Ozel, Ayse B.
AU - Li, Jun Z.
AU - Fleck, Brian W.
AU - Zeller, Tanja
AU - Staffieri, Sandra E.
AU - Teo, Yik Ying
AU - Cuellar-Partida, Gabriel
AU - Luo, Xiaoyan
AU - Allingham, R. Rand
AU - Richards, Julia E.
AU - Senft, Andrea
AU - Karssen, Lennart C.
AU - Zheng, Yingfeng
AU - Bellenguez, Céline
AU - Xu, Liang
AU - Iglesias, Adriana I.
AU - Wilson, James F.
AU - Kang, Jae Hee
AU - Van Leeuwen, Elisabeth M.
AU - Jonsson, Vesteinn
AU - Thorsteinsdottir, Unnur
AU - Despriet, Dominiek D.G.
AU - Ennis, Sarah
AU - Moroi, Sayoko E.
AU - Martin, Nicholas G.
AU - Jansonius, Nomdo M.
AU - Yazar, Seyhan
AU - Pasquale, Louis R.
N1 - Publisher Copyright:
© 2014 Nature America, Inc. All rights reserved.
PY - 2014/9/26
Y1 - 2014/9/26
N2 - Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10 '8 for rs6445055), two on chromosome 9 (P = 2.80 × 10 '11 for rs2472493 near ABCA1 and P = 6.39 × 10 '11 for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10 '11 for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
AB - Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10 '8 for rs6445055), two on chromosome 9 (P = 2.80 × 10 '11 for rs2472493 near ABCA1 and P = 6.39 × 10 '11 for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10 '11 for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
UR - https://www.scopus.com/pages/publications/84919382642
U2 - 10.1038/ng.3087
DO - 10.1038/ng.3087
M3 - Article
C2 - 25173106
AN - SCOPUS:84919382642
SN - 1061-4036
VL - 46
SP - 1126
EP - 1130
JO - Nature Genetics
JF - Nature Genetics
IS - 10
ER -