Genetics of obsessive-compulsive disorder and related disorders

Heidi A. Browne; Shannon L. Gair; Jeremiah M. Scharf; Dorothy E. Grice

doi:10.1016/j.psc.2014.06.002

Genetics of obsessive-compulsive disorder and related disorders

Heidi A. Browne
, Shannon L. Gair
, Jeremiah M. Scharf
, Dorothy E. Grice

Research output: Contribution to journal › Review article › peer-review

63 Scopus citations

Abstract

Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

Original language	English
Pages (from-to)	319-335
Number of pages	17
Journal	Psychiatric Clinics of North America
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.psc.2014.06.002
State	Published - Sep 2014

Keywords

Candidate gene
Familial recurrence
GWAS
Genetics
Heritability
Model system
OCD
Twin study

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10.1016/j.psc.2014.06.002

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@article{546a0ee756994a6bb397e4738c5b5055,

title = "Genetics of obsessive-compulsive disorder and related disorders",

abstract = "Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.",

keywords = "Candidate gene, Familial recurrence, GWAS, Genetics, Heritability, Model system, OCD, Twin study",

author = "Browne, \{Heidi A.\} and Gair, \{Shannon L.\} and Scharf, \{Jeremiah M.\} and Grice, \{Dorothy E.\}",

note = "Funding Information: Disclosures: J.M. Scharf has received research support from the National Institutes of Health , grants U01 NS40024 and K02 NS085048 and the Tourette Syndrome Association (TSA) and serves on the TSA Scientific Advisory Board. He has received travel support from the TSA and from the European Commission (COST Action BM0905) . D. E. Grice has received research support from the National Institutes of Health, grant R01 MH092516 , the Tourette Syndrome Association (TSA), and the Tourette Syndrome Association of New Jersey . The other authors have no relevant financial or nonfinancial disclosures. ",

year = "2014",

month = sep,

doi = "10.1016/j.psc.2014.06.002",

language = "English",

volume = "37",

pages = "319--335",

journal = "Psychiatric Clinics of North America",

issn = "0193-953X",

publisher = "W.B. Saunders",

number = "3",

}

TY - JOUR

T1 - Genetics of obsessive-compulsive disorder and related disorders

AU - Browne, Heidi A.

AU - Gair, Shannon L.

AU - Scharf, Jeremiah M.

AU - Grice, Dorothy E.

N1 - Funding Information: Disclosures: J.M. Scharf has received research support from the National Institutes of Health , grants U01 NS40024 and K02 NS085048 and the Tourette Syndrome Association (TSA) and serves on the TSA Scientific Advisory Board. He has received travel support from the TSA and from the European Commission (COST Action BM0905) . D. E. Grice has received research support from the National Institutes of Health, grant R01 MH092516 , the Tourette Syndrome Association (TSA), and the Tourette Syndrome Association of New Jersey . The other authors have no relevant financial or nonfinancial disclosures.

PY - 2014/9

Y1 - 2014/9

N2 - Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

AB - Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

KW - Candidate gene

KW - Familial recurrence

KW - GWAS

KW - Genetics

KW - Heritability

KW - Model system

KW - OCD

KW - Twin study

UR - https://www.scopus.com/pages/publications/84906316968

U2 - 10.1016/j.psc.2014.06.002

DO - 10.1016/j.psc.2014.06.002

M3 - Review article

C2 - 25150565

AN - SCOPUS:84906316968

SN - 0193-953X

VL - 37

SP - 319

EP - 335

JO - Psychiatric Clinics of North America

JF - Psychiatric Clinics of North America

IS - 3

ER -

Genetics of obsessive-compulsive disorder and related disorders

Abstract

Keywords

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