Genetics of obsessive-compulsive disorder and related disorders

Heidi A. Browne, Shannon L. Gair, Jeremiah M. Scharf, Dorothy E. Grice

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

Original languageEnglish
Pages (from-to)319-335
Number of pages17
JournalPsychiatric Clinics of North America
Issue number3
StatePublished - Sep 2014


  • Candidate gene
  • Familial recurrence
  • GWAS
  • Genetics
  • Heritability
  • Model system
  • OCD
  • Twin study


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