Genetics of Dementia

Anne L. Brunkan, Alison M. Goate

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Recognition that genes play an important role in determining risk for Alzheimer’s disease (AD) in the majority of cases is a recent phenomenon and is the direct result of molecular genetic studies during the last two decades. We now know that AD is a complex disease with multiple causes, although the underlying mechanism may be similar in all cases. Early-onset familial AD (FAD) is linked to specific rare, highly penetrant mutations (1). In contrast, risk for late-onset AD is likely the result of a combination of genetic and environmental risk factors. Interactions between AD genes and the environment are still poorly defined. However, studies from the past 10-15 years have given many insights into genes that play a role in AD and have produced models of the underlying molecular interactions that lead to disease.

Original languageEnglish
Title of host publicationHandbook of Dementing Illnesses, Second Edition
PublisherCRC Press
Number of pages11
ISBN (Electronic)9780849354847
ISBN (Print)9780824758387
StatePublished - 1 Jan 2006
Externally publishedYes


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