@article{980701084f854945a89f2587e65166f4,
title = "Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program",
abstract = "The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical phenotypes extracted from electronic health records covering a median of 10.0 years of follow-up. Among 297,626 veterans with at least one blood lipid measurement, including 57,332 black and 24,743 Hispanic participants, we tested up to around 32 million variants for association with lipid levels and identified 118 novel genome-wide significant loci after meta-analysis with data from the Global Lipids Genetics Consortium (total n > 600,000). Through a focus on mutations predicted to result in a loss of gene function and a phenome-wide association study, we propose novel indications for pharmaceutical inhibitors targeting PCSK9 (abdominal aortic aneurysm), ANGPTL4 (type 2 diabetes) and PDE3B (triglycerides and coronary disease).",
author = "{The Geisinger-Regeneron DiscovEHR Collaboration} and {the VA Million Veteran Program} and {Global Lipids Genetics Consortium} and {Myocardial Infarction Genetics (MIGen) Consortium} and Derek Klarin and Damrauer, {Scott M.} and Kelly Cho and Sun, {Yan V.} and Teslovich, {Tanya M.} and Jacqueline Honerlaw and Gagnon, {David R.} and DuVall, {Scott L.} and Jin Li and Peloso, {Gina M.} and Mark Chaffin and Small, {Aeron M.} and Jie Huang and Hua Tang and Lynch, {Julie A.} and Ho, {Yuk Lam} and Liu, {Dajiang J.} and Emdin, {Connor A.} and Li, {Alexander H.} and Huffman, {Jennifer E.} and Lee, {Jennifer S.} and Pradeep Natarajan and Rajiv Chowdhury and Danish Saleheen and Marijana Vujkovic and Aris Baras and Saiju Pyarajan and {Di Angelantonio}, Emanuele and Neale, {Benjamin M.} and Aliya Naheed and Khera, {Amit V.} and John Danesh and Chang, {Kyong Mi} and Gon{\c c}alo Abecasis and Cristen Willer and Dewey, {Frederick E.} and Carey, {David J.} and John Concato and Gaziano, {J. Michael} and O{\textquoteright}Donnell, {Christopher J.} and Tsao, {Philip S.} and Sekar Kathiresan and Rader, {Daniel J.} and Wilson, {Peter W.F.} and Assimes, {Themistocles L.}",
note = "Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2018",
month = nov,
day = "1",
doi = "10.1038/s41588-018-0222-9",
language = "English",
volume = "50",
pages = "1514--1523",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}