Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease

Robert S. Rosenson, Michael H. Davidson, Benjamin J. Hirsh, Sekar Kathiresan, Daniel Gaudet

Research output: Contribution to journalReview articlepeer-review

192 Scopus citations

Abstract

Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.

Original languageEnglish
Pages (from-to)2525-2540
Number of pages16
JournalJournal of the American College of Cardiology
Volume64
Issue number23
DOIs
StatePublished - 2014

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Genetics
  • Triglyceride
  • Triglyceride-rich lipoproteins

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