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Psoriasis (Ps) is a complex multifactorial disease, similar to other autoimmune or inflammatory diseases such as type 1 diabetes, Crohn’s disease (CD), and celiac disease. In all of these conditions, susceptibility is influenced by both genetic and environmental factors. The worldwide prevalence of Ps differs. For example, it is 3% in Europeans, 1 whereas it is only 0.1% in Asians. 2 Ps is a polygenic disease meaning that there are many genetic factors of low risk in the genome that can increase an individual’s risk of developing disease. As with other autoimmune diseases, some of these genetic factors are likely to lead to disease by encoding factors that cumulatively overcome a threshold for immune cell activation. 3 There is also overlap between some of these risk factors in the different autoimmune diseases. In the case of Ps, a single genetic mutation can also lead to a strong risk of developing disease. These genetic findings are discussed in the following with particular reference to their altered function.

Original languageEnglish
Title of host publicationPsoriasis, Second Edition
PublisherCRC Press
Number of pages14
ISBN (Electronic)9781498700535
ISBN (Print)9781498700528
StatePublished - 1 Jan 2017
Externally publishedYes


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