@inbook{b0dcd0e0d2f249e5b932f4df8c7ef30f,
title = "Genetically encoded nanoparticles for neural modulation",
abstract = "Regulating the activity of genetically and/or anatomically defined neurons is invaluable in trying to determine the physiological role of specific neural populations. Existing tools for neural activation and inhibition such as optogenetics and chemogenetics have transformed our understanding of neural circuits but they are not universally applicable. This chapter describes a system for remote, bidirectional regulation of neural activity in vivo controlled by noninvasive electromagnetic signals (Stanley et al. Nature 531:647–650, 2016). Using targeted expression of modified temperature sensitive channels and genetically encoded ferritin to generate intracellular nanoparticles, it is possible to activate or inhibit genetically targeted neurons using radiofrequency (RF) or magnetic fields. This technology provides an additional technique for rapid neural regulation in freely moving organisms.",
keywords = "Ferritin, Magnetogenetics, Nanoparticles, Radiogenetics, Transient receptor potential vanilloid 1 receptor",
author = "Stanley, {Sarah A.}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media LLC.",
year = "2018",
doi = "10.1007/978-1-4939-7584-6_5",
language = "English",
series = "Neuromethods",
publisher = "Humana Press Inc.",
pages = "53--67",
booktitle = "Neuromethods",
}