Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

Orna Levran; Einat Peles; Matthew Randesi; Joel Correa Da Rosa; Pei Hong Shen; John Rotrosen; Miriam Adelson; Mary Jeanne Kreek

doi:10.2217/pgs-2017-0179

Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

Orna Levran, Einat Peles, Matthew Randesi, Joel Correa Da Rosa, Pei Hong Shen, John Rotrosen, Miriam Adelson, Mary Jeanne Kreek

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13 Scopus citations

Abstract

Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.

Original language	English
Pages (from-to)	333-341
Number of pages	9
Journal	Pharmacogenomics
Volume	19
Issue number	4
DOIs	https://doi.org/10.2217/pgs-2017-0179
State	Published - Mar 2018

Keywords

CRHBP
HPA axis
NPY1R
NPY5R
abstinence
glucocorticoid receptor
stress resilience

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10.2217/pgs-2017-0179

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title = "Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin",

abstract = "Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.",

keywords = "CRHBP, HPA axis, NPY1R, NPY5R, abstinence, glucocorticoid receptor, stress resilience",

author = "Orna Levran and Einat Peles and Matthew Randesi and \{Correa Da Rosa\}, Joel and Shen, \{Pei Hong\} and John Rotrosen and Miriam Adelson and Kreek, \{Mary Jeanne\}",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = mar,

doi = "10.2217/pgs-2017-0179",

language = "English",

volume = "19",

pages = "333--341",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

AU - Levran, Orna

AU - Peles, Einat

AU - Randesi, Matthew

AU - Correa Da Rosa, Joel

AU - Shen, Pei Hong

AU - Rotrosen, John

AU - Adelson, Miriam

AU - Kreek, Mary Jeanne

PY - 2018/3

Y1 - 2018/3

N2 - Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.

AB - Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.

KW - CRHBP

KW - HPA axis

KW - NPY1R

KW - NPY5R

KW - abstinence

KW - glucocorticoid receptor

KW - stress resilience

UR - https://www.scopus.com/pages/publications/85043257186

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DO - 10.2217/pgs-2017-0179

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AN - SCOPUS:85043257186

SN - 1462-2416

VL - 19

SP - 333

EP - 341

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 4

ER -

Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

Abstract

Keywords

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