Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

Orna Levran, Einat Peles, Matthew Randesi, Joel Correa Da Rosa, Pei Hong Shen, John Rotrosen, Miriam Adelson, Mary Jeanne Kreek

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalPharmacogenomics
Volume19
Issue number4
DOIs
StatePublished - Mar 2018

Keywords

  • CRHBP
  • HPA axis
  • NPY1R
  • NPY5R
  • abstinence
  • glucocorticoid receptor
  • stress resilience

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