Genetic variations and transplant outcomes

Bernd Krüger, Bernd Schröppel

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Extensive genetic variation has been described in molecules regulating innate and adaptive immunity, pharmacokinetics, coagulation, and fibrosis. However, large prospective studies need to be performed to define the clinical consequences of such variation and the potential benefits of genotyping these markers for patients. The purpose of this review is to summarize recent data describing associations of polymorphisms in both immunological and non-immunological molecules with transplant outcomes, and discuss their clinical implications and limitations.

Original languageEnglish
Pages (from-to)c49-c54
JournalNephron - Clinical Practice
Volume118
Issue number1
DOIs
StatePublished - Nov 2010

Keywords

  • Acute rejection
  • Allograft survival
  • Cardiovascular mortality
  • Delayed graft function
  • Functional genetic variants
  • Kidney transplantation
  • Posttransplant metabolic complications

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