TY - JOUR
T1 - Genetic Testing for Heritable Cardiovascular Diseases in Pediatric Patients
T2 - A Scientific Statement From the American Heart Association
AU - Landstrom, Andrew P.
AU - Kim, Jeffrey J.
AU - Gelb, Bruce D.
AU - Helm, Benjamin M.
AU - Kannankeril, Prince J.
AU - Semsarian, Christopher
AU - Sturm, Amy C.
AU - Tristani-Firouzi, Martin
AU - Ware, Stephanie M.
N1 - Publisher Copyright:
© 2021 American Heart Association, Inc.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Genetic diseases that affect the cardiovascular system are relatively common and include cardiac channelopathies, cardiomyopathies, aortopathies, hypercholesterolemias, and structural diseases of the heart and great vessels. The rapidly expanding availability of clinical genetic testing leverages decades of research into the genetic origins of these diseases, helping inform diagnosis, clinical management, and prognosis. Although a number of guidelines and statements detail best practices for cardiovascular genetic testing, there is a paucity of pediatric-focused statements addressing the unique challenges in testing in this vulnerable population. In this scientific statement, we seek to coalesce the existing literature around the use of genetic testing for cardiovascular disease in infants, children, and adolescents.
AB - Genetic diseases that affect the cardiovascular system are relatively common and include cardiac channelopathies, cardiomyopathies, aortopathies, hypercholesterolemias, and structural diseases of the heart and great vessels. The rapidly expanding availability of clinical genetic testing leverages decades of research into the genetic origins of these diseases, helping inform diagnosis, clinical management, and prognosis. Although a number of guidelines and statements detail best practices for cardiovascular genetic testing, there is a paucity of pediatric-focused statements addressing the unique challenges in testing in this vulnerable population. In this scientific statement, we seek to coalesce the existing literature around the use of genetic testing for cardiovascular disease in infants, children, and adolescents.
KW - AHA Scientific Statements
KW - cardiomyopathies
KW - channelopathies
KW - connective tissue diseases
KW - counseling, genetic
KW - predictive genetic testing
UR - http://www.scopus.com/inward/record.url?scp=85119458111&partnerID=8YFLogxK
U2 - 10.1161/HCG.0000000000000086
DO - 10.1161/HCG.0000000000000086
M3 - Review article
C2 - 34412507
AN - SCOPUS:85119458111
SN - 1942-325X
VL - 14
SP - E000086
JO - Circulation. Genomic and precision medicine
JF - Circulation. Genomic and precision medicine
IS - 5
ER -