Genetic studies of typical Alzheimer's disease

Richard C. Mohs; David A. Greenberg; Jeremy M. Silverman

doi:10.1016/0197-4580(89)90089-4

Genetic studies of typical Alzheimer's disease

Richard C. Mohs
, David A. Greenberg
, Jeremy M. Silverman

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Typical, late-onset Alzheimer's disease is familial but shows no clear Mendelian pattern of inheritance. Strategies that could help to reveal its genetics are: 1) identification of genetically homogeneous phenotypes, 2) identification of early or alternate manifestations of AD gene expression in relatives, and 3) use of small multiplex families with cases of typical AD for linkage studies.

Original language	English
Pages (from-to)	438-439
Number of pages	2
Journal	Neurobiology of Aging
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/0197-4580(89)90089-4
State	Published - 1989

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title = "Genetic studies of typical Alzheimer's disease",

abstract = "Typical, late-onset Alzheimer's disease is familial but shows no clear Mendelian pattern of inheritance. Strategies that could help to reveal its genetics are: 1) identification of genetically homogeneous phenotypes, 2) identification of early or alternate manifestations of AD gene expression in relatives, and 3) use of small multiplex families with cases of typical AD for linkage studies.",

author = "Mohs, \{Richard C.\} and Greenberg, \{David A.\} and Silverman, \{Jeremy M.\}",

note = "Funding Information: The research described has been supported in part by the IWONL Institute, the NFWO Foundation, the National Incentive-Program on Fundamental Research in Life Sciences, the Born Bunge Foundation and Innogenetics, Belgium.",

year = "1989",

doi = "10.1016/0197-4580(89)90089-4",

language = "English",

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journal = "Neurobiology of Aging",

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publisher = "Elsevier Inc.",

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T1 - Genetic studies of typical Alzheimer's disease

AU - Mohs, Richard C.

AU - Greenberg, David A.

AU - Silverman, Jeremy M.

N1 - Funding Information: The research described has been supported in part by the IWONL Institute, the NFWO Foundation, the National Incentive-Program on Fundamental Research in Life Sciences, the Born Bunge Foundation and Innogenetics, Belgium.

PY - 1989

Y1 - 1989

N2 - Typical, late-onset Alzheimer's disease is familial but shows no clear Mendelian pattern of inheritance. Strategies that could help to reveal its genetics are: 1) identification of genetically homogeneous phenotypes, 2) identification of early or alternate manifestations of AD gene expression in relatives, and 3) use of small multiplex families with cases of typical AD for linkage studies.

AB - Typical, late-onset Alzheimer's disease is familial but shows no clear Mendelian pattern of inheritance. Strategies that could help to reveal its genetics are: 1) identification of genetically homogeneous phenotypes, 2) identification of early or alternate manifestations of AD gene expression in relatives, and 3) use of small multiplex families with cases of typical AD for linkage studies.

UR - https://www.scopus.com/pages/publications/0024376659

U2 - 10.1016/0197-4580(89)90089-4

DO - 10.1016/0197-4580(89)90089-4

M3 - Article

C2 - 2812205

AN - SCOPUS:0024376659

SN - 0197-4580

VL - 10

SP - 438

EP - 439

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 5

ER -

Genetic studies of typical Alzheimer's disease

Abstract

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