TY - CHAP
T1 - Genetic studies of IgA nephropathy
T2 - What have we learned from genome-wide association studies
AU - Xie, Jingyuan
AU - Shapiro, Samantha
AU - Gharavi, Ali
PY - 2013
Y1 - 2013
N2 - Primary IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. It is most common in Asian populations, followed by Caucasians, yet relatively infrequent amongst African populations. The striking difference in the prevalence of IgAN between world populations, together with the known familial aggregation of disease, suggests an inherited mechanism. Recently three genome-wide association studies (GWAS) of IgAN have identified seven susceptibility loci, providing initial insight into the genetic architecture of this trait. While genetic studies of complex traits are challenging, applying new techniques and methods of analysis, especially Next-Generation Sequencing, will push the genetic studies of IgAN forward.
AB - Primary IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. It is most common in Asian populations, followed by Caucasians, yet relatively infrequent amongst African populations. The striking difference in the prevalence of IgAN between world populations, together with the known familial aggregation of disease, suggests an inherited mechanism. Recently three genome-wide association studies (GWAS) of IgAN have identified seven susceptibility loci, providing initial insight into the genetic architecture of this trait. While genetic studies of complex traits are challenging, applying new techniques and methods of analysis, especially Next-Generation Sequencing, will push the genetic studies of IgAN forward.
UR - https://www.scopus.com/pages/publications/84879104331
U2 - 10.1159/000348652
DO - 10.1159/000348652
M3 - Chapter
C2 - 23689567
AN - SCOPUS:84879104331
SN - 9783318023893
T3 - Contributions to Nephrology
SP - 52
EP - 64
BT - New Insights into Glomerulonephritis
ER -