TY - JOUR
T1 - Genetic stratification of depression in UK Biobank
AU - Howard, David M.
AU - Folkersen, Lasse
AU - Coleman, Jonathan R.I.
AU - Adams, Mark J.
AU - Glanville, Kylie
AU - Werge, Thomas
AU - Hagenaars, Saskia P.
AU - Han, Buhm
AU - Porteous, David
AU - Campbell, Archie
AU - Clarke, Toni Kim
AU - Breen, Gerome
AU - Sullivan, Patrick F.
AU - Wray, Naomi R.
AU - Lewis, Cathryn M.
AU - McIntosh, Andrew M.
N1 - Funding Information:
This research was conducted using the UK Biobank resource, application number 4844. We are grateful to the UK Biobank and all its voluntary participants. The UK Biobank study was conducted under generic approval from the NHS National Research Ethics Service (approval letter dated 17 June 2011, Ref 11/NW/0382). All participants gave full informed written consent. D. M.H is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Reference 213674/Z/18/Z) and a 2018 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (Ref: 27404). A.M.McI acknowledges support from the Wellcome Trust (Wellcome Trust Strategic Award ‘STratifying Resilience and Depression Longitudinally’ (STRADL) Reference 104036/Z/14/Z and The Sackler Trust. N.R.W. acknowledges NMHRC grants 1078901 and 1087889. C.M.L acknowledges MRC grant MR/N015746/1. S.P.H. acknowledges MRC grant MR/S0151132. This investigation represents independent research part-funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.
AB - Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.
UR - http://www.scopus.com/inward/record.url?scp=85085383475&partnerID=8YFLogxK
U2 - 10.1038/s41398-020-0848-0
DO - 10.1038/s41398-020-0848-0
M3 - Article
C2 - 32448866
AN - SCOPUS:85085383475
SN - 2158-3188
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 163
ER -