TY - JOUR
T1 - Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease
AU - Miltenberger-Miltenyi, Gabriel
AU - Ortega, Roberto A.
AU - Domingo, Aloysius
AU - Yadav, Rachita
AU - Nishiyama, Ayumi
AU - Raymond, Deborah
AU - Katsnelson, Viktoriya
AU - Urval, Nikita
AU - Swan, Matthew
AU - Shanker, Vicki
AU - Miravite, Joan
AU - Walker, Ruth H.
AU - Bressman, Susan B.
AU - Ozelius, Laurie J.
AU - Cabassa, José C.
AU - Saunders-Pullman, Rachel
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.
AB - There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.
UR - https://www.scopus.com/pages/publications/85178916241
U2 - 10.1038/s41531-023-00599-6
DO - 10.1038/s41531-023-00599-6
M3 - Article
AN - SCOPUS:85178916241
SN - 2373-8057
VL - 9
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 160
ER -