Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

Gabriel Miltenberger-Miltenyi; Roberto A. Ortega; Aloysius Domingo; Rachita Yadav; Ayumi Nishiyama; Deborah Raymond; Viktoriya Katsnelson; Nikita Urval; Matthew Swan; Vicki Shanker; Joan Miravite; Ruth H. Walker; Susan B. Bressman; Laurie J. Ozelius; José C. Cabassa; Rachel Saunders-Pullman

doi:10.1038/s41531-023-00599-6

Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

Gabriel Miltenberger-Miltenyi, Roberto A. Ortega, Aloysius Domingo, Rachita Yadav, Ayumi Nishiyama, Deborah Raymond, Viktoriya Katsnelson, Nikita Urval, Matthew Swan, Vicki Shanker, Joan Miravite, Ruth H. Walker, Susan B. Bressman, Laurie J. Ozelius, José C. Cabassa, Rachel Saunders-Pullman

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.

Original language	English
Article number	160
Journal	npj Parkinson's Disease
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41531-023-00599-6
State	Published - Dec 2023

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Miltenberger-Miltenyi, G., Ortega, R. A., Domingo, A., Yadav, R., Nishiyama, A., Raymond, D., Katsnelson, V., Urval, N., Swan, M., Shanker, V., Miravite, J., Walker, R. H., Bressman, S. B., Ozelius, L. J., Cabassa, J. C., & Saunders-Pullman, R. (2023). Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease. npj Parkinson's Disease, 9(1), Article 160. https://doi.org/10.1038/s41531-023-00599-6

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title = "Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson{\textquoteright}s disease",

abstract = "There is a paucity of genetic characterization in people with Parkinson{\textquoteright}s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.",

author = "Gabriel Miltenberger-Miltenyi and Ortega, {Roberto A.} and Aloysius Domingo and Rachita Yadav and Ayumi Nishiyama and Deborah Raymond and Viktoriya Katsnelson and Nikita Urval and Matthew Swan and Vicki Shanker and Joan Miravite and Walker, {Ruth H.} and Bressman, {Susan B.} and Ozelius, {Laurie J.} and Cabassa, {Jos{\'e} C.} and Rachel Saunders-Pullman",

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doi = "10.1038/s41531-023-00599-6",

language = "English",

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Miltenberger-Miltenyi, G, Ortega, RA, Domingo, A, Yadav, R, Nishiyama, A, Raymond, D, Katsnelson, V, Urval, N, Swan, M , Shanker, V , Miravite, J , Walker, RH , Bressman, SB, Ozelius, LJ, Cabassa, JC & Saunders-Pullman, R 2023, 'Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease', npj Parkinson's Disease, vol. 9, no. 1, 160. https://doi.org/10.1038/s41531-023-00599-6

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T1 - Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

AU - Miltenberger-Miltenyi, Gabriel

AU - Ortega, Roberto A.

AU - Domingo, Aloysius

AU - Yadav, Rachita

AU - Nishiyama, Ayumi

AU - Raymond, Deborah

AU - Katsnelson, Viktoriya

AU - Urval, Nikita

AU - Swan, Matthew

AU - Shanker, Vicki

AU - Miravite, Joan

AU - Walker, Ruth H.

AU - Bressman, Susan B.

AU - Ozelius, Laurie J.

AU - Cabassa, José C.

AU - Saunders-Pullman, Rachel

PY - 2023/12

Y1 - 2023/12

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AB - There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.

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DO - 10.1038/s41531-023-00599-6

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AN - SCOPUS:85178916241

SN - 2373-8057

VL - 9

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

M1 - 160

ER -

Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

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